Dead-space and calculated by the Koulouris method do not represent true Bohr dead-space and respectively, but the shunt-corrected equation performs well. We propose that measuring respiratory gas exchange enables detection and quantification of these abnormalities. Some apparatus dead space may actually reduce total dead space, as an ETT bypasses the majority of anatomical dead space of the patient (nasopharynx).ĭead space from the patient. Our studies show that increased pulmonary shunt causes an apparent increase in V dphys, and that abnormal distributions affect the calculated V dphys and V dalv, but not Fowler dead-space. Background Pathological evidence suggests that COVID-19 pulmonary infection involves both alveolar damage (causing shunt) and diffuse micro-vascular thrombus formation (causing alveolar dead space). Types of Dead Spaceĭead space from equipment, such as tubes ventilator circuitry. additional mechanisms that can contribute to an elevated physiological dead space measurement include shunt, a substantial increase in overall VA/Q ratio, diffusion impairment, and ventilation delivered to unperfused alveolar. Glomerular Filtration and Tubular Functionĭead space is the proportion of minute ventilation which does not participate in gas exchange. 1 Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle, WA, USA. Functional Anatomy and Control of Blood Flow
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